Antibiotic susceptibility pattern of Escherichia colifrom urine samples in cancer patients

1 Oct 2019 Research

Raji Baidya, Sumitra Gurung, Sumal Maharjan, Bijesh Raj Ghimire, Sudip Shrestha, Microbiology Unit, Laboratory Science & Transfusion Services, Nepal Cancer Hospital and Research Center Pvt. Ltd., Harisiddhi, Lalitpur, Nepal, 2016.



Escherichia coli are the most common cause of urinary tract infection (UTI) in healthcare settings. The rapid increase in the rates of antibiotic resistance among E. coli has resulted into limited treatment option and poses a greater challenge when infections are due to multidrug-resistant E. coli. Hence, it is becoming a global concern.


The aim of this study was to determine the antimicrobial susceptibility of E. coli from clinical urine samples.


The retrospective study of culture results of urine samples was conducted to determine the antibiotic susceptibility pattern. A total 1010urinesamples were analyzed out of which 260 positive growth urine samples were reviewed for isolation & identification of bacteria and antimicrobial susceptibility testing.


E. coli was isolated from 111 (42.49%) samples.E. coli showed high resistance rates to amoxicillin (79.59%), amoxicillin-clavulanate (71.43), cefixime (70.37%) &ciprofloxacin (63.83%) were recorded. However, greater degree of sensitivity rates to nitrofurantoin (87.76%),imipenem (82.61%), cefoperazone-sulbactam (76.19%), amikacin (70.79%) were documented.


This study suggested that E. coli isolates showed higher resistance rate to amoxicillin, amoxicillin-clavulanate, cefixime, ciprofloxacin. Whereas nitrofurantoin, imipenem, cefoperazone-sulbactam, amikacin are considered appropriate for empirical treatment of E. coli in the study area. The regular monitoring of antibiotic susceptibility is required.

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